Leukemia

Leukemias are a group of hematologic disorders characterized by the dysfunctional proliferation and development of leukocytes. Acute Lymphoblastic Leukemia (ALL), Acute Myelogenous Leukemia (AML), Chronic Lymphocytic Leukemia (CLL) and Chronic Myelogenous Leukemia (CML) are the 4 major subtypes of leukemia.

CD Markers in Leukemia

The CD (cluster of differentiation) markers are frequently used in differential diagnosis of leukemia. Detection of changes in CD marker expression in leukemia is critical for understand the primary mechanisms initiating these changes.

OriGene offers a range of tools to analyze CD markers including cDNA clones, antibodies, overexpression cell lysates and more. Click the buttons below for details.

CD7 CD10 CD13 CD20 CD23 CD33 CD52 CD79a CD138 CD205

Leukemia markers stained with OriGene’s Ultra Specific Antibodies

CD10 in MDA-MB-453 cell pellets stained with UM800128
CD10 in MDA-MB-453 cell pellets stained with UM800128
CD10 in Human Kidney stained with UM800128
CD10 in Human Kidney stained with UM800128
CD10 in SK-MEL-28 cell pellets stained with UM800127
CD10 in SK-MEL-28 cell pellets stained with UM800127
CD10 in Mouse Kidney stained with UM800127
CD10 in Mouse Kidney stained with UM800127
CD20 in Jurkat cells stained with UM800009
CD20 in Jurkat cells stained with UM800009
CD20 in Human Lymphoma tissue stained with UM800009
CD20 in Human Lymphoma tissue stained with UM800009
CD13 in Human Lymphoma tissue stained UM800165
CD13 in Human Lymphoma tissue stained UM800165
MLF1  in Human Colon tissue stained with UM500100
MLF1 in Human Colon tissue stained with UM500100

Leukemia Stems cells in Acute Myeloid Leukemia (AML)

Leukemia stem cells (LSCs)play a critical role in the initiation, progression and treatment resistance in AML. Developing markers for LSCs and understanding the molecular mechanisms of LSCs is critical for developing better targeting strategies.

OriGene offers a range of tools to analyze CD markers including cDNA clones, antibodies, overexpression cell lysates and more. Click the buttons below for details.

CD34 CD38 CD123 TIM3 CD9 HDACs NF-kB HIF-1α β-catenin

Leukemia Stem Cell markers stained with OriGene’s Ultra Specific and TrueMAB Antibodies

HT-29 cells stained
				for β-catenin with ultra specific antibody (UM500015)
HT-29 cells stained for β-catenin with ultra specific antibody (UM500015)
Mouse Colon tissue stained for β-catenin with ultra specific antibody (UM500015)
Mouse Colon tissue stained for β-catenin with ultra specific antibody (UM500015)
Human Colon tissue stained for CD38 with ultra specific antibody (UM800153)
Human Colon tissue stained for CD38 with ultra specific antibody (UM800153)
Flow cytometric analysis of HAVCR2 expression  using TrueMAB antibody (TA812500)
Flow cytometric analysis of HA VCR2 expression using TrueMAB antibody (TA812500)
Human Kidney stained for HDAC9 with TrueMAB antibody TA805328
Human Kidney stained for HDAC9 with TrueMAB antibody TA805328
RCC4 cells stained
				for HIF-1 α using TrueMAB antibody TA336308
RCC4 cells stained for HIF-1 α using TrueMAB antibody TA336308
Flow cytometric
				analysis of CD9 expression in Hela cells using TrueMAB antibody
				(TA813476)
Flow cytometric analysis of CD9 expression in Hela cells using TrueMAB antibody (TA813476)
Sequential double
				staining for β-catenin (UM500015-red), PD1 (UM800091-brown)
Sequential double staining for β-catenin (UM500015-red), PD1 (UM800091-brown)

Explore the gene specific tools for leukemia research



  1. Leukemia, Iyengar and Shimanovsky, https://pubmed.ncbi.nlm.nih.gov/32809325/
  2. The biomarkers of LSCs in AML, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5388677/pdf/sci-04-2017.02.10.pdf