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Target Symbol
- MEK1 (15)
- NATRIURETIC PEPTIDE RECEPTOR C (14)
- RAB21 (14)
- MEK3 (10)
- DRP1 (8)
- ACAA2 (7)
- LEUKOTRIENE A4 HYDROLASE (7)
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- GLUCOSE 6 PHOSPHATE ISOMERASE (3)
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- MEK4 (3)
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- NNMT (3)
- NOTCH1 (3)
- PI 3 KINASE CLASS 2A (3)
- PP5 (3)
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- PTCH1 (3)
- RFXANK (3)
- RPL7A (3)
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- EZH2 (2)
- FAF1 (2)
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- FHIT (2)
Antibody Hosts
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Conjugates
Carrier-free
Knockout (KO) Validation
Families
- Druggable Genome (452)
- Transcription Factors (112)
- Transmembrane (97)
- Protein Kinase (92)
- ES Cell Differentiation/IPS (46)
- Protease (41)
- Stem cell - Pluripotency (36)
- Secreted Protein (30)
- Adult stem cells (8)
- Nuclear Hormone Receptor (8)
- Stem cell relevant signaling - JAK/STAT signaling pathway (8)
- Stem cell relevant signaling - TGFb/BMP signaling pathway (6)
- Cancer stem cells (5)
- Embryonic stem cells (5)
- P450 (5)
- Stem cell relevant signaling - DSL/Notch pathway (5)
- Induced pluripotent stem cells (4)
- Phosphatase (3)
- Stem cell relevant signaling - Wnt Signaling pathway (3)
- Ion Channels: Cys-loop Receptors (2)
- Ion Channels: Other (2)
- Ion Channels: Potassium (2)
- GPCR (1)
Pathways
- Metabolic pathways (104)
- Pathways in cancer (71)
- MAPK signaling pathway (53)
- Fc epsilon RI signaling pathway (50)
- Prostate cancer (50)
- Focal adhesion (49)
- Colorectal cancer (47)
- ErbB signaling pathway (46)
- Progesterone-mediated oocyte maturation (44)
- Toll-like receptor signaling pathway (44)
- Endometrial cancer (43)
- Fc gamma R-mediated phagocytosis (42)
- Neurotrophin signaling pathway (40)
- GnRH signaling pathway (37)
- Non-small cell lung cancer (36)
- Regulation of actin cytoskeleton (36)
- Acute myeloid leukemia (35)
- Insulin signaling pathway (34)
- Pancreatic cancer (34)
- Renal cell carcinoma (34)
- B cell receptor signaling pathway (32)
- Chronic myeloid leukemia (32)
- T cell receptor signaling pathway (32)
- Melanoma (31)
- Glioma (30)
- VEGF signaling pathway (30)
- Bladder cancer (29)
- Chemokine signaling pathway (29)
- Thyroid cancer (29)
- Natural killer cell mediated cytotoxicity (27)
- Melanogenesis (26)
- Gap junction (23)
- Cell cycle (22)
- Leukocyte transendothelial migration (22)
- Oocyte meiosis (22)
- Vascular smooth muscle contraction (22)
- Wnt signaling pathway (22)
- Dorso-ventral axis formation (21)
- Prion diseases (21)
- Purine metabolism (21)
- Small cell lung cancer (21)
- Type II diabetes mellitus (21)
- Amyotrophic lateral sclerosis (ALS) (20)
- Jak-STAT signaling pathway (19)
- Valine (19)
- leucine and isoleucine degradation (19)
- Adherens junction (18)
- Endocytosis (18)
- Long-term depression (18)
- Long-term potentiation (18)
- Fatty acid metabolism (17)
- Glycolysis / Gluconeogenesis (16)
- Tight junction (16)
- Ubiquitin mediated proteolysis (16)
- Apoptosis (15)
- Propanoate metabolism (14)
- mTOR signaling pathway (14)
- Pathogenic Escherichia coli infection (13)
- Pyruvate metabolism (13)
- Arginine and proline metabolism (12)
- Basal cell carcinoma (12)
- Epithelial cell signaling in Helicobacter pylori infection (12)
- Phosphatidylinositol signaling system (12)
- Adipocytokine signaling pathway (10)
- Arachidonic acid metabolism (10)
- Pyrimidine metabolism (10)
- Spliceosome (10)
- TGF-beta signaling pathway (10)
- Butanoate metabolism (9)
- Lysine degradation (9)
- RNA degradation (9)
- Tryptophan metabolism (9)
- Alzheimer's disease (8)
- Axon guidance (8)
- Base excision repair (8)
- Calcium signaling pathway (8)
- Glutathione metabolism (8)
- Primary immunodeficiency (8)
- Proteasome (8)
- Arrhythmogenic right ventricular cardiomyopathy (ARVC) (7)
- DNA replication (7)
- Fatty acid elongation in mitochondria (7)
- Renin-angiotensin system (7)
- Terpenoid backbone biosynthesis (7)
- Tyrosine metabolism (7)
- p53 signaling pathway (7)
- Drug metabolism - cytochrome P450 (6)
- Hedgehog signaling pathway (6)
- Histidine metabolism (6)
- Nucleotide excision repair (6)
- One carbon pool by folate (6)
- Synthesis and degradation of ketone bodies (6)
- beta-Alanine metabolism (6)
- Antigen processing and presentation (5)
- Caffeine metabolism (5)
- Drug metabolism - other enzymes (5)
- Inositol phosphate metabolism (5)
- Notch signaling pathway (5)
- Parkinson's disease (5)
- Retinol metabolism (5)
- ABC transporters (4)
- Amino sugar and nucleotide sugar metabolism (4)
- Fatty acid biosynthesis (4)
- Glycerolipid metabolism (4)
- Mismatch repair (4)
- Neuroactive ligand-receptor interaction (4)
- Nicotinate and nicotinamide metabolism (4)
- Oxidative phosphorylation (4)
- Pentose phosphate pathway (4)
- RIG-I-like receptor signaling pathway (4)
- Starch and sucrose metabolism (4)
- Alanine (3)
- Androgen and estrogen metabolism (3)
- Cell adhesion molecules (CAMs) (3)
- Cysteine and methionine metabolism (3)
- NOD-like receptor signaling pathway (3)
- Ribosome (3)
- Selenoamino acid metabolism (3)
- Vibrio cholerae infection (3)
- aspartate and glutamate metabolism (3)
- Aminoacyl-tRNA biosynthesis (2)
- Citrate cycle (TCA cycle) (2)
- Cytokine-cytokine receptor interaction (2)
- Folate biosynthesis (2)
- Hematopoietic cell lineage (2)
- Huntington's disease (2)
- Linoleic acid metabolism (2)
- Metabolism of xenobiotics by cytochrome P450 (2)
- PPAR signaling pathway (2)
- Regulation of autophagy (2)
- Steroid biosynthesis (2)
- Systemic lupus erythematosus (2)
- Thiamine metabolism (2)
- Ascorbate and aldarate metabolism (1)
- Cardiac muscle contraction (1)
- Complement and coagulation cascades (1)
- Dilated cardiomyopathy (1)
- Fructose and mannose metabolism (1)
- Glycerophospholipid metabolism (1)
- Glyoxylate and dicarboxylate metabolism (1)
- Hypertrophic cardiomyopathy (HCM) (1)
- Limonene and pinene degradation (1)
- Lysosome (1)
- Maturity onset diabetes of the young (1)
- Nitrogen metabolism (1)
- Porphyrin and chlorophyll metabolism (1)
- Protein export (1)
- SNARE interactions in vesicular transport (1)
- Sulfur metabolism (1)
- Taurine and hypotaurine metabolism (1)
- Type I diabetes mellitus (1)
- Vitamin B6 metabolism (1)