NXF1 Human shRNA Plasmid Kit (Locus ID 10482)

SKU TR311051

NXF1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided

Product Data

• Locus ID: 10482
• Synonyms: MEX67; TAP
• Vector: pRS
• E. coli Selection: Ampicillin
• Format: Retroviral plasmids
• Components: NXF1 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 10482). 5µg purified plasmid DNA per construct; 29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free.
• RefSeq: NM_001081491, NM_006362, NM_006362.1, NM_006362.2, NM_006362.3, NM_006362.4, NM_001081491.1, BC028041, BC028041.1, BC004904, BC017421, BM751313, NM_001081491.2, NM_006362.5
• UniProt ID: Q9UBU9
• Summary: This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene shuttles between the nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. It is the vertebrate homologue of the yeast protein Mex67p. The encoded protein overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
• shRNA Design: These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
• Shipping: Ambient