SIAH1 Human shRNA Plasmid Kit (Locus ID 6477)

SKU TL316726

SIAH1 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided

Product Data

• Locus ID: 6477
• Synonyms: BURHAS; SIAH1A
• Vector: pGFP-C-shLenti
• E. coli Selection: Chloramphenicol (34 ug/ml)
• Format: Lentiviral plasmids
• Components: SIAH1 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 6477). 5µg purified plasmid DNA per construct; 29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
• RefSeq: NM_001006610, NM_001006611, NM_003031, NM_003031.1, NM_003031.2, NM_003031.3, NM_001006610.1, BC042550, BC042550.1, BC018193, BC035562, BC044920, NM_001006610.2
• UniProt ID: Q8IUQ4
• Summary: This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
• shRNA Design: These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
• Shipping: Ambient