Caspase 1 (CASP1) Human shRNA Plasmid Kit (Locus ID 834)
SKU
TL305640
CASP1 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
$1,013.00
In Stock*
Specifications
| Product Data | |
| Locus ID | 834 |
|---|---|
| Synonyms | ICE; IL1BC; P45 |
| Vector | pGFP-C-shLenti |
| E. coli Selection | Chloramphenicol (34 ug/ml) |
| Mammalian Cell Selection | Puromycin |
| Format | Lentiviral plasmids |
| Components | CASP1 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 834). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free. |
| RefSeq | NM_001223, NM_001257118, NM_001257119, NM_033292, NM_033293, NM_033294, NM_033295, NM_033293.1, NM_033293.2, NM_033293.3, NM_033292.1, NM_033292.2, NM_033292.3, NM_033294.1, NM_033294.2, NM_033294.3, NM_001223.1, NM_001223.2, NM_001223.3, NM_001223.4, NM_033295.1, NM_033295.2, NM_033295.3, NM_001257119.1, NM_001257119.2, NM_001257118.1, NM_001257118.2, BC062327, BC062327.1, BC041689, NM_001257118.3, NM_001257119.3, NM_033292.4, NM_001223.5, NM_033293.4 |
| UniProt ID | P29466 |
| Summary | This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms. provided by RefSeq, Mar 2012 |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
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