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INSIG1 Human shRNA Plasmid Kit (Locus ID 3638)

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TL303916
INSIG1 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
In Control Promo
  $1,013.00
2 Weeks*

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Other products for "INSIG1 or NM_005542"

Specifications
Specifications
Product Data
Locus ID 3638
Synonyms CL6
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components INSIG1 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 3638). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq NM_005542, NM_198336, NM_198337, NM_001346590, NM_001346591, NM_001346592, NM_001346593, NM_001346594, NM_005542.1, NM_005542.2, NM_005542.3, NM_005542.4, NM_005542.5, NM_198336.1, NM_198336.2, NM_198336.3, NM_198337.1, NM_198337.3, BC001880, BC001880.1, BM995866, NM_005542.6
UniProt ID O15503
Summary This gene encodes an endoplasmic reticulum membrane protein that regulates cholesterol metabolism, lipogenesis, and glucose homeostasis. The encoded protein has six transmembrane helices which contain an effector protein binding site. It binds the sterol-sensing domains of sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP) and 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase), and is essential for the sterol-mediated trafficking of these two proteins. It promotes the endoplasmic reticulum retention of SCAP and the ubiquitin-mediated degradation of HMG-CoA reductase. Alternative splicing results in multiple transcript variants. provided by RefSeq, Oct 2016
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.