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PHF19 Human shRNA Plasmid Kit (Locus ID 26147)

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SKU
TL302509
PHF19 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
In Control Promo
  $1,013.00
2 Weeks*

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Specifications
Specifications
Product Data
Locus ID 26147
Synonyms MTF2L1; PCL3; TDRD19B
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components PHF19 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 26147). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq NM_001009936, NM_001286840, NM_001286842, NM_001286843, NM_015651, NR_104601, NM_001009936.1, NM_001009936.2, NM_015651.1, NM_015651.2, NM_001286843.1, NM_001286842.1, NM_001286840.1, BC125076, BC022374, BC044224, BC108663, BC125077, BM784783, BM784790, NM_001286843.2, NM_015651.3, NM_001009936.3
UniProt ID Q5T6S3
Summary Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Probably involved in the transition from an active state to a repressed state in embryonic stem cells: acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting H3K36me3 histone demethylases RIOX1 or KDM2B, leading to demethylation of H3K36 and recruitment of the PRC2 complex that mediates H3K27me3 methylation, followed by de novo silencing. Recruits the PRC2 complex to CpG islands and contributes to embryonic stem cell self-renewal. Also binds dimethylated at 'Lys-36' (H3K36me2). Isoform 1 and isoform 2 inhibit transcription from an HSV-tk promoter.UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.