Shugoshin (SGO1) Human shRNA Plasmid Kit (Locus ID 151648)
SKU
TL301731
SGO1 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
$1,013.00
In Stock*
Specifications
| Product Data | |
| Locus ID | 151648 |
|---|---|
| Synonyms | CAID; NY-BR-85; SGO; SGOL1 |
| Vector | pGFP-C-shLenti |
| E. coli Selection | Chloramphenicol (34 ug/ml) |
| Format | Lentiviral plasmids |
| Components | SGO1 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 151648). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free. |
| RefSeq | NM_001012409, NM_001012410, NM_001012411, NM_001012412, NM_001012413, NM_001199251, NM_001199252, NM_001199253, NM_001199254, NM_001199255, NM_001199256, NM_001199257, NM_138484, NR_131179, NR_131180, NM_138484.1, NM_138484.3, NM_138484.4, NM_001012410.1, NM_001012410.2, NM_001012410.3, NM_001012410.4, NM_001012411.1, NM_001012411.2, NM_001012411.3, NM_001012409.1, NM_001012409.2, NM_001012413.1, NM_001012413.2, NM_001012413.3, NM_001012412.1, NM_001012412.2, NM_001012412.3, NM_001012412.4, NM_001199257.1, NM_001199257.2, NM_001199255.1, NM_001199255.2, NM_001199253.1, NM_001199253.2, NM_001199256.1, NM_001199256.2, NM_001199254.1, NM_001199254.2, NM_001199251.1, NM_001199251.2, NM_001199252.1, NM_001199252.2, BC017867, BC017867.1, BC001339, BC032696, BC039605, BM144963, NM_138484.5, NM_001012410.5, NM_001199251.3, NM_001012412.5, NM_001199252.3, NM_001199254.3, NM_001199257.3, NM_001199256.3 |
| UniProt ID | Q5FBB7 |
| Summary | The protein encoded by this gene is a member of the shugoshin family of proteins. This protein is thought to protect centromeric cohesin from cleavage during mitotic prophase by preventing phosphorylation of a cohesin subunit. Reduced expression of this gene leads to the premature loss of centromeric cohesion, mis-segregation of sister chromatids, and mitotic arrest. Evidence suggests that this protein also protects a small subset of cohesin found along the length of the chromosome arms during mitotic prophase. An isoform lacking exon 6 has been shown to play a role in the cohesion of centrioles (PMID: 16582621 and PMID:18331714). Mutations in this gene have been associated with Chronic Atrial and Intestinal Dysrhythmia (CAID) syndrome, characterized by the co-occurrence of Sick Sinus Syndrome (SSS) and Chronic Intestinal Pseudo-obstruction (CIPO) within the first four decades of life (PMID:25282101). Fibroblast cells from CAID patients exhibited both increased cell proliferation and higher rates of senescence. Pseudogenes of this gene have been found on chromosomes 1 and 7. Alternative splicing results in multiple transcript variants. provided by RefSeq, Mar 2015 |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Shipping | Ambient |
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