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Picalm Mouse shRNA Plasmid (Locus ID 233489)

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TG516729
Picalm - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
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  $883.00
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Specifications
Specifications
Product Data
Locus ID 233489
Synonyms CALM; CLTH; fit-1; fit1; mKIAA4114; PAP180
Vector pGFP-V-RS
E. coli Selection Kanamycin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Picalm - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 233489). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
RefSeq BC011470, BC021491, BC023843, BC025566, BC057683, NM_001252520, NM_001252521, NM_001252522, NM_001252523, NM_001252524, NM_146194, NM_001360867, NM_146194.1, NM_146194.2, NM_146194.3, NM_146194.4, NM_001252524.1, NM_001252523.1, NM_001252522.1, NM_001252521.1, NM_001252520.1, BC011470.1, BC025566.1, BC027116, NM_001252520.2, NM_001252521.2, NM_001252523.2, NM_001252522.2, NM_001252524.2, NM_146194.5
UniProt ID Q7M6Y3
Summary Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly. Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature. In addition to binding to clathrin, mediates the endocytosis of small R-SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8. In turn, PICALM-dependent SNARE endocytosis is required for the formation and maturation of autophagic precursors. Modulates thereby autophagy and the turnover of autophagy substrates such as MAPT/TAU or amyloid precursor protein cleaved C-terminal fragment (APP-CTF).UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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