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Nrp1 Mouse shRNA Plasmid (Locus ID 18186)

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TG513573
Nrp1 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 18186
Synonyms C530029I03; NP-1; NPN-1; Npn1; Nrp
Vector pGFP-V-RS
E. coli Selection Kanamycin
Format Retroviral plasmids
Components Nrp1 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 18186). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
RefSeq BC060129, NM_008737, NM_001358959, NM_001358960, NM_008737.1, NM_008737.2, BC006184, BC026730, BC032048, BC038657, BC051447
UniProt ID P97333
Summary Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. Mediates the chemorepulsant activity of semaphorins. Binds to semaphorin 3A, the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB. Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulates VEGF-induced angiogenesis (By similarity). Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (PubMed:26503042).UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
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