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Pik3r1 Mouse shRNA Plasmid (Locus ID 18708)

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TG509680
Pik3r1 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
  $883.00
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Other products for "Pik3r1 or NM_001024955"

Specifications
Specifications
Product Data
Locus ID 18708
Synonyms p50alpha; p55alpha; p85alpha; PI3K
Vector pGFP-V-RS
E. coli Selection Kanamycin
Format Retroviral plasmids
Components Pik3r1 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 18708). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
RefSeq BC026146, BC051106, NM_001024955, NM_001077495, NM_011085, NM_001077495.1, NM_001077495.2, NM_001024955.1, NM_001024955.2, BC002168, BM963795
UniProt ID P26450
Summary Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (By similarity). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348926).UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
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