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Nr1h3 Mouse shRNA Plasmid (Locus ID 22259)

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TG502381
Nr1h3 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 22259
Synonyms AU018371; LXR; RLD1; Unr1
Vector pGFP-V-RS
E. coli Selection Kanamycin
Format Retroviral plasmids
Components Nr1h3 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 22259). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
RefSeq BC012646, NM_001177730, NM_013839, NM_001355279, NM_013839.1, NM_013839.2, NM_013839.3, NM_013839.4, NM_001177730.1
UniProt ID Q9Z0Y9
Summary Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:18055760, PubMed:19520913, PubMed:20427281). Interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism.UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
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