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IRE1 (ERN1) Human shRNA Plasmid Kit (Locus ID 2081)

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TG320345
ERN1 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 2081
Synonyms hIRE1p; IRE1; IRE1a; IRE1P
Vector pGFP-V-RS
E. coli Selection Kanamycin
Format Retroviral plasmids
Components ERN1 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 2081). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
RefSeq NM_001433, NM_152461, NM_001433.1, NM_001433.2, NM_001433.3, NM_152461.2, BC070350, BC130405, BC130407, NM_001433.5
UniProt ID O75460
Summary This gene encodes the transmembrane protein kinase inositol-requiring enzyme 1. The encoded protein contains two functional catalytic domains, a serine/threonine-protein kinase domain and an endoribonuclease domain. This protein functions as a sensor of unfolded proteins in the endoplasmic reticulum (ER) and triggers an intracellular signaling pathway termed the unfolded protein response (UPR). The UPR is an ER stress response that is conserved from yeast to mammals and activates genes involved in degrading misfolded proteins, regulating protein synthesis and activating molecular chaperones. This protein specifically mediates the splicing and activation of the stress response transcription factor X-box binding protein 1. provided by RefSeq, Aug 2017
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
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