Nicotinic Acetylcholine Receptor alpha 7 (CHRNA7) Human shRNA Plasmid Kit (Locus ID 1139)
SKU
TG313917
CHRNA7 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
$883.00
In Stock*
Specifications
| Product Data | |
| Locus ID | 1139 |
|---|---|
| Synonyms | CHRNA7-2; NACHRA7 |
| Vector | pGFP-V-RS |
| E. coli Selection | Kanamycin |
| Format | Retroviral plasmids |
| Components | CHRNA7 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 1139). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free. |
| RefSeq | NM_000746, NM_001190455, NR_046324, NM_000746.1, NM_000746.2, NM_000746.3, NM_000746.4, NM_000746.5, NM_001190455.1, NM_001190455.2, BC037571, BC037571.1, BM451308, NM_001190455.3, NM_000746.6 |
| UniProt ID | P36544 |
| Summary | The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene. Alternative splicing results in multiple transcript variants. provided by RefSeq, Feb 2012 |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Shipping | Ambient |
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