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Epac1 (RAPGEF3) Human shRNA Plasmid Kit (Locus ID 10411)

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SKU
TG309939
RAPGEF3 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
  $883.00
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Other products for "Epac1 or NM_001098531"

Specifications
Specifications
Product Data
Locus ID 10411
Synonyms bcm910; CAMP-GEFI; EPAC; EPAC1; HSU79275
Vector pGFP-V-RS
E. coli Selection Kanamycin
Format Retroviral plasmids
Components RAPGEF3 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 10411). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
RefSeq NM_001098531, NM_001098532, NM_006105, NM_006105.1, NM_006105.2, NM_006105.3, NM_006105.4, NM_006105.5, NM_001098531.1, NM_001098531.2, NM_001098532.1, NM_001098532.2, BC017728, BC040534, BC068477, BC092404, NM_001098531.3
UniProt ID O95398
Summary Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin.UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
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