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SPATA2 Human shRNA Plasmid Kit (Locus ID 9825)

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TG309156
SPATA2 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
In Control Promo
  $883.00
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Other products for "SPATA2 or NM_001135773"

Specifications
Specifications
Product Data
Locus ID 9825
Synonyms PD1; PPP1R145; tamo
Vector pGFP-V-RS
E. coli Selection Kanamycin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components SPATA2 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 9825). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
RefSeq NM_001135773, NM_006038, NM_006038.1, NM_006038.2, NM_006038.3, NM_001135773.1, BC009481, BC009481.2, NM_006038.4
UniProt ID Q9UM82
Summary Bridging factor that mediates the recruitment of CYLD to the LUBAC complex, thereby regulating TNF-alpha-induced necroptosis (PubMed:27307491, PubMed:27458237, PubMed:27545878, PubMed:27591049). Acts as a direct binding intermediate that bridges RNF31/HOIP, the catalytic subunit of the LUBAC complex, and the deubiquitinase (CYLD), thereby recruiting CYLD to the TNF-R1 signaling complex (TNF-RSC) (PubMed:27458237, PubMed:27545878, PubMed:27591049). Required to activate the 'Met-1'- (linear) and 'Lys-63'-linked deubiquitinase activities of CYLD (PubMed:27458237, PubMed:27591049). Controls the kinase activity of RIPK1 and TNF-alpha-induced necroptosis by promoting 'Met-1'-linked deubiquitination of RIPK1 by CYLD (By similarity).UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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