G protein alpha S (GNAS) Human shRNA Plasmid Kit (Locus ID 2778)
SKU
TG304299
GNAS - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
$883.00
In Stock*
Specifications
| Product Data | |
| Locus ID | 2778 |
|---|---|
| Synonyms | AHO; C20orf45; GNAS1; GPSA; GSA; GSP; NESP; PITA3; POH; SCG6; SgVI |
| Vector | pGFP-V-RS |
| E. coli Selection | Kanamycin |
| Format | Retroviral plasmids |
| Components | GNAS - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 2778). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free. |
| RefSeq | NM_000516, NM_001077488, NM_001077489, NM_001077490, NM_001309840, NM_001309842, NM_001309861, NM_001309883, NM_016592, NM_080425, NM_080426, NR_003259, NR_132272, NR_132273, NM_016592.1, NM_016592.2, NM_016592.3, NM_000516.1, NM_000516.2, NM_000516.3, NM_000516.4, NM_000516.5, NM_080425.1, NM_080425.2, NM_080425.3, NM_080426.1, NM_080426.2, NM_080426.3, NM_001077489.1, NM_001077489.2, NM_001077489.3, NM_001077490.1, NM_001077490.2, NM_001077488.1, NM_001077488.2, NM_001077488.3, BC002722, BC008855, BC022875, BC036081, BC066923, BC089157, BC104928, BC108315, BM894355, NM_080426.4, NM_001077488.5, NM_001077489.4, NM_016592.5, NM_000516.7 |
| UniProt ID | Q5JWF2 |
| Summary | This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors. provided by RefSeq, Aug 2012 |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Shipping | Ambient |
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.