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HMBOX1 Human shRNA Plasmid Kit (Locus ID 79618)

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TG304081
HMBOX1 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 79618
Synonyms HNF1LA; HOT1; PBHNF; TAH1
Vector pGFP-V-RS
E. coli Selection Kanamycin
Format Retroviral plasmids
Components HMBOX1 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 79618). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
RefSeq NM_001135726, NM_024567, NM_001324382, NM_001324383, NM_001324384, NM_001324385, NM_001324386, NM_001324387, NM_001324388, NM_001324389, NM_001324390, NM_001324391, NM_001324392, NM_001324393, NM_001324394, NM_001324395, NM_001330498, NR_136757, NR_136758, NM_024567.1, NM_024567.2, NM_024567.3, NM_024567.4, NM_001135726.1, NM_001135726.2, BC069242, BC069242.1, BC009259, NM_001135726.3
UniProt ID Q6NT76
Summary Binds directly to 5'-TTAGGG-3' repeats in telomeric DNA (PubMed:23813958, PubMed:23685356). Associates with the telomerase complex at sites of active telomere processing and positively regulates telomere elongation (PubMed:23685356). Important for TERT binding to chromatin, indicating a role in recruitment of the telomerase complex to telomeres (By similarity). Also plays a role in the alternative lengthening of telomeres (ALT) pathway in telomerase-negative cells where it promotes formation and/or maintenance of ALT-associated promyelocytic leukemia bodies (APBs) (PubMed:23813958). Enhances formation of telomere C-circles in ALT cells, suggesting a possible role in telomere recombination (PubMed:23813958). Might also be involved in the DNA damage response at telomeres (PubMed:23813958).UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
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