Vegfa Mouse shRNA Plasmid (Locus ID 22339)
SKU
TF510369
Vegfa - Mouse, 4 unique 29mer shRNA constructs in retroviral RFP vector, 5µg of each construct provided
$883.00
In Stock*
Specifications
| Product Data | |
| Locus ID | 22339 |
|---|---|
| Synonyms | V; Veg; Vegf; VEGF12; VEGF16; VEGF18; Vpf |
| Vector | pRFP-C-RS |
| E. coli Selection | Chloramphenicol (34 ug/ml) |
| Format | Retroviral plasmids |
| Components | Vegfa - Mouse, 4 unique 29mer shRNA constructs in retroviral RFP vector(Gene ID = 22339). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pRFP-C-RS Vector, TR30015, included for free. |
| RefSeq | BC061468, NM_001025250, NM_001025257, NM_001110266, NM_001110267, NM_001110268, NM_001287056, NM_001287057, NM_001287058, NM_009505, NM_001025250.1, NM_001025250.2, NM_001025250.3, NM_009505.1, NM_009505.2, NM_009505.3, NM_009505.4, NM_001025257.1, NM_001025257.2, NM_001025257.3, NM_001110266.1, NM_001110267.1, NM_001110268.1, NM_001287058.1, NM_001287057.1, NM_001287056.1, BC022642 |
| UniProt ID | Q00731 |
| Summary | This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site.provided by RefSeq, Nov 2015 |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Shipping | Ambient |
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