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DNMT3B Human shRNA Plasmid Kit (Locus ID 1789)

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TF320324
DNMT3B - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 1789
Synonyms ICF; ICF1; M.HsaIIIB
Vector pRFP-C-RS
E. coli Selection Chloramphenicol (34 ug/ml)
Format Retroviral plasmids
Components DNMT3B - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector(Gene ID = 1789). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRFP-C-RS Vector, TR30015, included for free.
RefSeq NM_001207055, NM_001207056, NM_006892, NM_175848, NM_175849, NM_175850, NM_175848.1, NM_175850.1, NM_175850.2, NM_006892.1, NM_006892.2, NM_006892.3, NM_175849.1, NM_001207056.1, NM_001207055.1, BC111933, BC118502, NM_006892.4, NM_001207055.2, NM_001207056.2, NM_175848.2, NM_175849.2
UniProt ID Q9UBC3
Summary CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Eight alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined. provided by RefSeq, May 2011
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
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