Amyloid Precursor Protein (APP) Human shRNA Plasmid Kit (Locus ID 351)
SKU
TF320264
APP - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector, 5µg of each construct provided
$883.00
In Stock*
Specifications
| Product Data | |
| Locus ID | 351 |
|---|---|
| Synonyms | AAA; ABETA; ABPP; AD1; alpha-sAPP; APPI; CTFgamma; CVAP; PN-II; PN2; preA4 |
| Vector | pRFP-C-RS |
| E. coli Selection | Chloramphenicol (34 ug/ml) |
| Format | Retroviral plasmids |
| Components | APP - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector(Gene ID = 351). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pRFP-C-RS Vector, TR30015, included for free. |
| RefSeq | NM_000484, NM_001136016, NM_001136129, NM_001136130, NM_001136131, NM_001204301, NM_001204302, NM_001204303, NM_201413, NM_201414, NM_201413.1, NM_201413.2, NM_201414.1, NM_201414.2, NM_000484.1, NM_000484.2, NM_000484.3, NM_001136016.1, NM_001136016.2, NM_001136016.3, NM_001136129.1, NM_001136129.2, NM_001136130.1, NM_001136130.2, NM_001136131.1, NM_001136131.2, NM_001204303.1, NM_001204302.1, NM_001204301.1, BC065529, BC065529.1, BC004369, BC065523, BM172428, BM876312, NM_001204303.2, NM_001204302.2, NM_201413.3, NM_001136130.3, NM_201414.3, NM_000484.4, NM_001136129.3, NM_001204301.2 |
| UniProt ID | P05067 |
| Summary | This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. provided by RefSeq, Aug 2014 |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Shipping | Ambient |
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