PSTPIP1 Human shRNA Plasmid Kit (Locus ID 9051)
SKU
TF310088
PSTPIP1 - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector, 5µg of each construct provided
$883.00
In Stock*
Specifications
| Product Data | |
| Locus ID | 9051 |
|---|---|
| Synonyms | CD2BP1; CD2BP1L; CD2BP1S; H-PIP; PAPAS; PSTPIP |
| Vector | pRFP-C-RS |
| E. coli Selection | Chloramphenicol (34 ug/ml) |
| Format | Retroviral plasmids |
| Components | PSTPIP1 - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector(Gene ID = 9051). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pRFP-C-RS Vector, TR30015, included for free. |
| RefSeq | NM_001321135, NM_001321136, NM_001321137, NM_003978, NR_135552, NM_003978.1, NM_003978.2, NM_003978.3, NM_003978.4, BC008602, BC008602.1, NM_003978.5 |
| UniProt ID | O43586 |
| Summary | This gene encodes a cytoskeletal protein that is highly expressed in hemopoietic tissues. This protein functions via its interaction with several different proteins involved in cytoskeletal organization and inflammatory processes. It binds to the cytoplasmic tail of CD2, an effector of T cell activation and adhesion, downregulating CD2-triggered adhesion. It binds PEST-type protein tyrosine phosphatases (PTP) and directs them to c-Abl kinase to mediate c-Abl dephosphorylation, thereby, regulating c-Abl activity. It also interacts with pyrin, which is found in association with the cytoskeleton in myeloid/monocytic cells and modulates immunoregulatory functions. Mutations in this gene are associated with PAPA (pyogenic sterile arthritis, pyoderma gangrenosum, and acne) syndrome. It is hypothesized that the disease-causing mutations compromise physiologic signaling necessary for the maintenance of a proper inflammatory response. provided by RefSeq, Mar 2016 |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Shipping | Ambient |
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