53BP1 (TP53BP1) Human shRNA Plasmid Kit (Locus ID 7158)
SKU
TF308691
TP53BP1 - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector, 5µg of each construct provided
$883.00
In Stock*
Specifications
| Product Data | |
| Locus ID | 7158 |
|---|---|
| Synonyms | 53BP1; p53BP1; p202; TDRD30 |
| Vector | pRFP-C-RS |
| E. coli Selection | Chloramphenicol (34 ug/ml) |
| Mammalian Cell Selection | Puromycin |
| Format | Retroviral plasmids |
| Components | TP53BP1 - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector(Gene ID = 7158). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pRFP-C-RS Vector, TR30015, included for free. |
| RefSeq | NM_001141979, NM_001141980, NM_005657, NM_001355001, NM_005657.1, NM_005657.2, NM_001141979.1, NM_001141980.1, BC017846, BC063119, BC112161, NM_001141979.3, NM_001141980.3, NM_005657.4 |
| UniProt ID | Q12888 |
| Summary | This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V(D)J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms. provided by RefSeq, Aug 2017 |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
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