DCTN1 Human shRNA Plasmid Kit (Locus ID 1639)
SKU
TF305084
DCTN1 - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector, 5µg of each construct provided
$883.00
In Stock*
Specifications
| Product Data | |
| Locus ID | 1639 |
|---|---|
| Synonyms | DAP-150; DP-150; P135 |
| Vector | pRFP-C-RS |
| E. coli Selection | Chloramphenicol (34 ug/ml) |
| Format | Retroviral plasmids |
| Components | DCTN1 - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector(Gene ID = 1639). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pRFP-C-RS Vector, TR30015, included for free. |
| RefSeq | NM_001135040, NM_001135041, NM_001190836, NM_001190837, NM_004082, NM_023019, NR_033935, NM_004082.1, NM_004082.2, NM_004082.3, NM_004082.4, NM_023019.1, NM_023019.2, NM_023019.3, NM_001135041.1, NM_001135041.2, NM_001135040.1, NM_001135040.2, NM_001190836.1, NM_001190837.1, BC071583, BC006163, BC013978, NM_001190837.2, NM_004082.5, NM_001135041.3, NM_001190836.2, NM_023019.4, NM_001135040.3 |
| UniProt ID | Q14203 |
| Summary | This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA). provided by RefSeq, Oct 2008 |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Shipping | Ambient |
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