DYRK1A Human shRNA Plasmid Kit (Locus ID 1859)
SKU
TF304866
DYRK1A - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector, 5µg of each construct provided
$883.00
In Stock*
Specifications
| Product Data | |
| Locus ID | 1859 |
|---|---|
| Synonyms | DYRK; DYRK1; HP86; MNB; MNBH; MRD7 |
| Vector | pRFP-C-RS |
| E. coli Selection | Chloramphenicol (34 ug/ml) |
| Format | Retroviral plasmids |
| Components | DYRK1A - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector(Gene ID = 1859). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pRFP-C-RS Vector, TR30015, included for free. |
| RefSeq | NM_001396, NM_101395, NM_130436, NM_130437, NM_130438, NM_001347721, NM_001347722, NM_001347723, NM_001396.1, NM_001396.2, NM_001396.3, NM_001396.4, NM_130436.1, NM_130436.2, NM_130438.1, NM_130438.2, NM_101395.1, NM_101395.2, NM_130437.1, BC030515, BC045802, BC065184, BC156309, BC172505 |
| UniProt ID | Q13627 |
| Summary | This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms. provided by RefSeq, Jul 2008 |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Shipping | Ambient |
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