PML Protein (PML) Human shRNA Plasmid Kit (Locus ID 5371)
SKU
TF302401
PML - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector, 5µg of each construct provided
$883.00
In Stock*
Specifications
| Product Data | |
| Locus ID | 5371 |
|---|---|
| Synonyms | MYL; PP8675; RNF71; TRIM19 |
| Vector | pRFP-C-RS |
| E. coli Selection | Chloramphenicol (34 ug/ml) |
| Format | Retroviral plasmids |
| Components | PML - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector(Gene ID = 5371). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pRFP-C-RS Vector, TR30015, included for free. |
| RefSeq | NM_002675, NM_033238, NM_033239, NM_033240, NM_033242, NM_033244, NM_033245, NM_033246, NM_033247, NM_033249, NM_033250, NM_033250.1, NM_033250.2, NM_033239.1, NM_033239.2, NM_002675.1, NM_002675.2, NM_002675.3, NM_033238.1, NM_033238.2, NM_033240.1, NM_033240.2, NM_033244.1, NM_033244.2, NM_033244.3, NM_033246.1, NM_033246.2, NM_033247.1, NM_033247.2, NM_033249.1, NM_033249.2, BC000080, BC020994, BC034251, BC139795, NM_033247.3, NM_033244.4, NM_033239.3, NM_033250.3, NM_033238.3 |
| UniProt ID | P29590 |
| Summary | The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. provided by RefSeq, Jul 2008 |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Shipping | Ambient |
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