SMAD3 (NM_005902) Human Recombinant Protein

CAT#: TP762386

Purified recombinant protein of Human SMAD family member 3 (SMAD3), transcript variant 1, Ser2-Ala230, with N-terminal His tag, expressed in E.coli, 50ug

Product Images

Purified recombinant protein SMAD3 was analyzed by SDS-PAGE gel and Coomossie Blue Staining.

Specifications

Product Data

• Species: Human
• Expression Host: E. coli
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  A DNA sequence encoding the region (Ser2-Ala230) of SMAD3
• Tag: N-His
• Predicted MW: 26.0 kDa
• Concentration: >0.05 µg/µL as determined by microplate BCA method
• Purity: >80% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: 50 mM Tris-HCl, pH 8.0, 8 M urea
• Note: For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
• Storage: Store at -80°C after receiving vials.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.

Reference Data

• RefSeq: NP_005893
• Locus ID: 4088
• UniProt ID: P84022, A0A024R5Z3, Q9P0T0
• Cytogenetics: 15q22.33
• Refseq Size: 6256
• Refseq ORF: 1275
• Synonyms: HSPC193; HsT17436; JV15-2; LDS1C; LDS3; MADH3
• Summary: The SMAD family of proteins are a group of intracellular signal transducer proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. The SMAD3 protein functions in the transforming growth factor-beta signaling pathway, and transmits signals from the cell surface to the nucleus, regulating gene activity and cell proliferation. It also functions as a tumor suppressor. Mutations in this gene are associated with aneurysms-osteoarthritis syndrome and Loeys-Dietz Syndrome 3. [provided by RefSeq, Nov 2019]
• Protein Families: Cancer stem cells, Druggable Genome, Embryonic stem cells, ES Cell Differentiation/IPS, Stem cell relevant signaling - JAK/STAT signaling pathway, Stem cell relevant signaling - TGFb/BMP signaling pathway, Transcription Factors
• Protein Pathways: Adherens junction, Cell cycle, Chronic myeloid leukemia, Colorectal cancer, Pancreatic cancer, Pathways in cancer, TGF-beta signaling pathway, Wnt signaling pathway