Cellular Apoptosis Susceptibility (CSE1L) (NM_001316) Human Recombinant Protein

CAT#: TP762224

Purified recombinant protein of Human CSE1 chromosome segregation 1-like (yeast) (CSE1L), Met1-Leu300, with N-terminal His tag, expressed in E.coli, 50ug


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USD 249.00

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Size
    • 50 ug

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Specifications

Product Data
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence
A DNA sequence encoding the region(Met1-Leu300) of CSE1L
Tag N-His
Predicted MW 34.9 kDa
Concentration >0.05 µg/µL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 50 mM Tris-HCl, pH 8.0, 8 M urea
Note For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Reference Data
RefSeq NP_001307
Locus ID 1434
UniProt ID P55060, A0A384NKW7
Cytogenetics 20q13.13
Refseq Size 3627
Refseq ORF 2913
Synonyms CAS; CSE1; XPO2
Summary Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]
Protein Families Druggable Genome

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