CYBB (NM_000397) Human Recombinant Protein

CAT#: TP762176

Purified recombinant protein of Human cytochrome b-245, beta polypeptide (CYBB), Glu283-End, with N-terminal His tag, expressed in E.coli, 50ug

Product images

Purified recombinant protein CYBB was analyzed by SDS-PAGE gel and Coomossie Blue Staining.

Specifications

Product Data

• Description: Purified recombinant protein of Human cytochrome b-245, beta polypeptide (CYBB), Glu283-End, with N-terminal His tag, expressed in E.coli, 50ug
• Species: Human
• Expression Host: E. coli
• Expression cDNA Clone or AA Sequence: A DNA sequence encoding the region(Glu283-End) of CYBB
• Tag: N-His
• Predicted MW: 33.2 kDa
• Concentration: >50 ug/mL as determined by microplate BCA method
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: 50mM Tris, 8M Urea, pH8.0.
• Storage: Store at -80°C.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.

Reference Data

• RefSeq: NP_000388
• Locus ID: 1536
• Refseq Size: 4353
• Cytogenetics: Xp21.1-p11.4
• Refseq ORF: 1710
• Synonyms: AMCBX2; CGD; GP91-1; GP91-PHOX; GP91PHOX; IMD34; NOX2; p91-PHOX
• Summary: Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole. [provided by RefSeq, Jul 2008]
• Protein Families: Druggable Genome, Ion Channels: Other, Transmembrane
• Protein Pathways: Leukocyte transendothelial migration