Prion protein PrP (PRNP) (NM_001080121) Human Recombinant Protein

CAT#: TP761951

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Purified recombinant protein of Human prion protein (PRNP), transcript variant 3,full length, with N-terminal GST and C-terminal His tag, expressed in E. coli, 50ug


 Product Datasheet for 'TP761951'

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USD 205.00


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    • 50 ug


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Product Data
Description Purified recombinant protein of Human prion protein (PRNP), transcript variant 3,full length, with N-terminal GST and C-terminal His tag, expressed in E. coli, 50ug
Species Human
Expression Host E. coli
Tag N-GST and C-His
Predicted MW 55.6 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol,1% Sarkosyl.
Reference Data
RefSeq NP_001073590
Locus ID 5621
Refseq Size 2750
Cytogenetics 20p13
Refseq ORF 759
Synonyms AltPrP; ASCR; CD230; CJD; GSS; KURU; p27-30; PRIP; PrP; PrP27-30; PrP33-35C; PrPc
Summary The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
Protein Families ES Cell Differentiation/IPS, Stem cell - Pluripotency, Transmembrane
Protein Pathways Prion diseases

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