LATS2 (NM_014572) Human Recombinant Protein

CAT#: TP761911

Purified recombinant protein of Human LATS, large tumor suppressor, homolog 2 (Drosophila) (LATS2), Met1-Ala237, with N-terminal HIS tag, expressed in E. coli, 50ug

Product images

Specifications

Product Data

• Description: Purified recombinant protein of Human LATS, large tumor suppressor, homolog 2 (Drosophila) (LATS2), Met1-Ala237, with N-terminal HIS tag, expressed in E. coli, 50ug
• Species: Human
• Expression Host: E. coli
• Expression cDNA Clone or AA Sequence: A DNA sequence encoding the region(Met1-Ala237) of LATS2
• Tag: N-His
• Predicted MW: 25.8 kDa
• Concentration: >50 ug/mL as determined by microplate BCA method
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: 25mM Tris, pH8.0,150 mM NaCl, 10% glycerol
• Storage: Store at -80°C.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.

Reference Data

• RefSeq: NP_055387
• Locus ID: 26524
• Refseq Size: 4098
• Cytogenetics: 13q12.11
• Refseq ORF: 3264
• Synonyms: KPM
• Summary: This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. [provided by RefSeq, Jul 2008]
• Protein Families: Druggable Genome, Protein Kinase