LATS2 (NM_014572) Human Recombinant Protein

CAT#: TP761911

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Purified recombinant protein of Human LATS, large tumor suppressor, homolog 2 (Drosophila) (LATS2), Met1-Ala237, with N-terminal HIS tag, expressed in E. coli, 50ug


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USD 205.00


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    • 50 ug


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Product Data
Description Purified recombinant protein of Human LATS, large tumor suppressor, homolog 2 (Drosophila) (LATS2), Met1-Ala237, with N-terminal HIS tag, expressed in E. coli, 50ug
Species Human
Expression Host E. coli
Tag N-His
Predicted MW 25.8 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25mM Tris, pH8.0,150 mM NaCl, 10% glycerol
Reference Data
RefSeq NP_055387
Locus ID 26524
Refseq Size 4098
Cytogenetics 13q12.11
Refseq ORF 3264
Synonyms KPM
Summary This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. [provided by RefSeq, Jul 2008]
Protein Families Druggable Genome, Protein Kinase

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