Cyclin D3 (CCND3) (NM_001760) Human Recombinant Protein

CAT#: TP761887

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Purified recombinant protein of Human cyclin D3 (CCND3), transcript variant 2, full length, with N-terminal GST and C-terminal His tag, expressed in E.coli, 50ug



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USD 215.00


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    • 50 ug


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Product Data
Description Purified recombinant protein of Human cyclin D3 (CCND3), transcript variant 2, full length, with N-terminal GST and C-terminal His tag, expressed in E.coli, 50ug
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence A DNA sequence encoding human full-length CCND3
Tag N-GST and C-His
Predicted MW 60.3 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25mM Tris, pH8.0,150mM NaCl,10% glycerol,1%Sarkosyl
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Reference Data
RefSeq NP_001751
Locus ID 896
Refseq Size 2095
Cytogenetics 6p21.1
Refseq ORF 876
Synonyms D3-type cyclin; G1/S-specific cyclin D3; OTTHUMP00000016390; cyclin D3
Summary The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Protein Families Druggable Genome
Protein Pathways Cell cycle, Focal adhesion, Jak-STAT signaling pathway, p53 signaling pathway, Wnt signaling pathway

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