TRIF (TICAM1) (NM_182919) Human Recombinant Protein

SKU TP761852

Purified recombinant protein of Human toll-like receptor adaptor molecule 1 (TICAM1), full length, with N-terminal GST and C-terminal His tag, expressed in E. coli, 50ug

Product Data

• Species: Human
• Expression Host: E. coli
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  A DNA sequence encoding human full-length TICAM1
• Tag: N-GST and C-His
• Predicted MW: 104.2 kDa
• Concentration: >0.05 µg/µL as determined by microplate BCA method
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: 50 mM Tris-HCl, pH 8.0, 8 M urea
• Note: For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
• Storage: Store at -80°C.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Shipping: Dry Ice

Reference Data

• RefSeq: NP_891549
• Locus ID: 148022
• UniProt ID: Q8IUC6
• Cytogenetics: 19p13.3
• RefSeq Size: 2460
• RefSeq ORF: 2136
• Synonyms: IIAE6; MyD88-3; PRVTIRB; TICAM-1; TRIF
• Summary: This gene encodes an adaptor protein containing a Toll/interleukin-1 receptor (TIR) homology domain, which is an intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. This protein is involved in native immunity against invading pathogens. It specifically interacts with toll-like receptor 3, but not with other TLRs, and this association mediates dsRNA induction of interferon-beta through activation of nuclear factor kappa-B, during an antiviral immune response. Mutations in this gene are associated with encephalopathy, acute, infection-induced. [provided by RefSeq, Jul 2020]
• Protein Families: Druggable Genome
• Protein Pathways: Toll-like receptor signaling pathway