FBXW7 (NM_001013415) Human Recombinant Protein

CAT#: TP761714

Reviews ()
Write a review

Purified recombinant protein of Human F-box and WD repeat domain containing 7 (FBXW7), transcript variant 3, full length, with N-terminal His tag, expressed in E. coli, 50ug


Product Datasheet for 'TP761714'


  View other "FBXW7" proteins (8)

USD 215.00


Availability*
In Stock

Size
    • 50 ug


Product images

Specifications

Product Data
Description Purified recombinant protein of Human F-box and WD repeat domain containing 7 (FBXW7), transcript variant 3, full length, with N-terminal His tag, expressed in E. coli, 50ug
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence A DNA sequence encoding human full-length FBXW7
Tag N-His
Predicted MW 65.9 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 50mM Tris, pH8.0,8M Urea.
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Reference Data
RefSeq NP_001013433
Locus ID 55294
Refseq Size 3570
Cytogenetics 4q31.3
Refseq ORF 1767
Synonyms AGO; CDC4; FBW6; FBW7; FBX30; FBXO30; FBXW6; hAgo; hCdc4; SEL-10; SEL10
Summary This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]
Protein Families Druggable Genome, Transmembrane
Protein Pathways Ubiquitin mediated proteolysis

Documents

Other Versions

Other products for "FBXW7"
Frequently bought together (1)
FBXW7 mouse monoclonal antibody, clone OTI6F5 (formerly 6F5)
    • 100 ul

USD 379.00

Customer Reviews 
Loading...
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
68 Mouse Clones
Molbio tools
HUMAN PROREINS 101