Caspase 9 (CASP9) (NM_001229) Human Recombinant Protein

CAT#: TP761193

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Purified recombinant protein of Human caspase 9, apoptosis-related cysteine peptidase (CASP9), transcript variant alpha, full length, with N-terminal HIS tag, expressed in E. coli, 50ug


Product Datasheet for 'TP761193'


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USD 215.00


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    • 50 ug


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Product Data
Description Purified recombinant protein of Human caspase 9, apoptosis-related cysteine peptidase (CASP9), transcript variant alpha, full length, with N-terminal HIS tag, expressed in E. coli, 50ug
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence A DNA sequence encoding human full-length CASP9
Tag N-His
Predicted MW 46.1 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 50mM Tris, 8M Urea, pH8.0.
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Reference Data
RefSeq NP_001220
Locus ID 842
Refseq Size 2034
Cytogenetics 1p36.21
Refseq ORF 1248
Synonyms APAF-3; APAF3; ICE-LAP6; MCH6; PPP1R56
Summary This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
Protein Families Druggable Genome, Protease, Stem cell - Pluripotency
Protein Pathways Alzheimer's disease, Amyotrophic lateral sclerosis (ALS), Apoptosis, Colorectal cancer, Endometrial cancer, Huntington's disease, Non-small cell lung cancer, p53 signaling pathway, Pancreatic cancer, Parkinson's disease, Pathways in cancer, Prostate cancer, Small cell lung cancer, VEGF signaling pathway, Viral myocarditis

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