GM CSF (CSF2) (NM_000758) Human Recombinant Protein
SKU
TP750271
Lyophilized purified recombinant protein of Human colony stimulating factor 2 (granulocyte-macrophage) (CSF2), Ala18-Glu144, tag free, 100ug
$540.00
3 Weeks*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | E. coli |
| Expression cDNA Clone or AA Sequence | |
| Tag | Tag Free |
| Predicted MW | 14.6 kDa |
| Purity | > 90% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4 |
| Bioactivity | Measured in a cell proliferation assay using TF-1 human erythroleukemic cells.The ED50 for this effect is 0.10-0.30ng/mL. |
| Endotoxin | < 0.1 EU per 1 µg of the protein by the LAL |
| Reconstitution Method | It is not recommended to reconstitute to a concentration less than 200 μg/mL in ddH2O. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Stability | Stored at -20 to -70°C for 1 year and avoid repeated freeze-thaw cycles after receipt; After reconstitution, the protein can be stored longer at -20 to -70°C, with aliquoting for single use recommended to prevent repeated freeze-thaw. |
| Shipping | Blue Ice |
| Reference Data | |
| RefSeq | NP_000749 |
| Locus ID | 1437 |
| UniProt ID | P04141 |
| Cytogenetics | 5q31.1 |
| Synonyms | CSF; GMCSF |
| Summary | The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. This gene plays a role in promoting tissue inflammation. Elevated levels of cytokines, including the one produced by this gene, have been detected in SARS-CoV-2 infected patients that develop acute respiratory distress syndrome. Mice deficient in this gene or its receptor develop pulmonary alveolar proteinosis. provided by RefSeq, Aug 2020 |
| Protein Categories | Cytokines, Growth Factors, Secreated Proteins |
| Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein |
| Protein Pathways | Cytokine-cytokine receptor interaction, Fc epsilon RI signaling pathway, Hematopoietic cell lineage, Jak-STAT signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.