Renin (REN) (NM_000537) Human Recombinant Protein

CAT#: TP750151

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Purified recombinant protein of Human renin (REN), 131Asp-End, with N-terminal HIS tag, expressed in E.Coli, 50 ug

  View other "REN" proteins (4)

USD 215.00

2 Weeks

    • 50 ug

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Product Data
Description Purified recombinant protein of Human renin (REN), 131Asp-End, with N-terminal HIS tag, expressed in E.Coli, 50 ug
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence A DNA sequence encoding the region( 131Asp-End) of REN
Predicted MW 30.2KDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 85% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1% Sarkosyl.
Storage Store at +4°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Reference Data
RefSeq NP_000528
Locus ID 5972
Refseq Size 1493
Cytogenetics 1q32.1
Refseq ORF 1218
Synonyms HNFJ2
Summary This gene encodes renin, an aspartic protease that is secreted by the kidneys. Renin is a part of the renin-angiotensin-aldosterone system involved in regulation of blood pressure, and electrolyte balance. This enzyme catalyzes the first step in the activation pathway of angiotensinogen by cleaving angiotensinogen to form angiotensin I, which is then converted to angiotensin II by angiotensin I converting enzyme. This cascade can result in aldosterone release, narrowing of blood vessels, and increase in blood pressure as angiotension II is a vasoconstrictive peptide. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause hyperuricemic nephropathy familial juvenile 2, familial hyperproreninemia, and renal tubular dysgenesis. [provided by RefSeq, May 2020]
Protein Families Druggable Genome, Secreted Protein
Protein Pathways Renin-angiotensin system


Other Versions

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REN mouse monoclonal antibody, clone OTI2F10 (formerly 2F10)
    • 100 ul

USD 379.00

Customer Reviews 
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