PDGF beta (PDGFB) (NM_002608) Human Recombinant Protein
SKU
TP750039
Purified recombinant protein of Human platelet-derived growth factor beta polypeptide (PDGF-BB), transcript variant 1, Ser82-Thr190, Tag free, expressed in E.coli, 50ug
$540.00
2 Weeks*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | E. coli |
| Expression cDNA Clone or AA Sequence | |
| Tag | Tag Free |
| Predicted MW | 12.4 kDa |
| Concentration | Resuspend the protein to the desired concentration in proper buffer. |
| Purity | > 90% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | Lyophilized from a sterile solution containing PBS, pH 7.4 |
| Endotoxin | < 0.1 EU per 1 µg of the protein by the LAL |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Stability | Stable for at least 1 year from receipt of products under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NP_002599 |
| Locus ID | 5155 |
| UniProt ID | P01127 A0A384NYY3 |
| Cytogenetics | 22q13.1 |
| RefSeq Size | 3393 |
| RefSeq ORF | 723 |
| Synonyms | c-sis; IBGC5; PDGF-2; PDGF2; SIS; SSV |
| Summary | This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit B, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit A. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with dermatofibrosarcoma protuberans, a rare skin tumor. Alternative splicing results in multiple transcript variants. provided by RefSeq, Oct 2015 |
| Protein Categories | Cancer: Brain and CNS, Cancer: Lung, Growth Factors, Intracellular Proteins, Nervous system: Neurodegenerative diseases, Secreated Proteins |
| Protein Families | Druggable Genome |
| Protein Pathways | Cytokine-cytokine receptor interaction, Focal adhesion, Gap junction, Glioma, MAPK signaling pathway, Melanoma, Pathways in cancer, Prostate cancer, Regulation of actin cytoskeleton, Renal cell carcinoma |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.