Oncostatin M (OSM) Human Recombinant Protein

SKU TP724654

Recombinant Human Oncostatin-M/OSM

Product Data

• Species: Human
• Protein Source: E. coli
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  A26-R221
• Buffer: Lyophilized from a 0.2 um filtered solution of PBS, pH7.4
• Note: Recombinant Human Oncostatin-M is produced by E.coli. The target gene encoding A26-R221 is expressed.
• Storage: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-5 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
• Stability: 12 months from date of despatch
• Shipping: Ambient

Reference Data

• Locus ID: 5008
• UniProt ID: P13725
• Synonyms: MGC20461; oncostatin M; oncostatin-M; OSM
• Summary: Oncostatin-M (OSM) is a glycoprotein that belongs to the interleukin-6 family of cytokines. OSM closely resembles leukemia inhibitory factor (LIF) in both structure and function. However, it is as yet poorly defined and is proving important in liver development, hematopoiesis, inflammation and possibly CNS development. OSM also plays a role in bone formation and destruction. OSM initiates its biological activities by binding to cell surface receptors that contain the protein gp130. OSM was previously identified by its ability to inhibit the growth of cells from melanoma and other solid tumors. Studies also showed that OSM, like LIF, IL-6 and G-CSF, can inhibit the proliferation of murine M1 myeloid leukemic cells and can induce their differentiation into macrophage-like cells.
• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein, Stem cell relevant signaling - DSL/Notch pathway, Stem cell relevant signaling - JAK/STAT signaling pathway
• Protein Pathways: Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway