MMP1 (NM_002421) Human Recombinant Protein

CAT#: TP723882

Purified recombinant protein of Human matrix metallopeptidase 1 (interstitial collagenase) (MMP1), transcript variant 1


 Product Datasheet for 'TP723882'

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USD 260.00


Availability*
5 Days

Size
    • 10 ug


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Specifications

Product Data
Description Purified recombinant protein of Human matrix metallopeptidase 1 (interstitial collagenase) (MMP1), transcript variant 1
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence Human MMP-1, the region of Phe20-Asn469, from gene Accession# NM_002421
Tag N-His
Predicted MW 54 kDa
Concentration Protein formulated and vialed at >50 ug/mL in specified buffer
Purity >90%, as determined by Coomassie stained SDS-PAGE.
Buffer 25 mM TRIS, 10 mM CaCl2, 150 mM NaCl, pH7.5
Bioactivity Human MMP-1 cleaves the peptide substrate Mca-KPLGL-Dpa-AR-NH2 with an activity above 200 pmol/min/µg.
Endotoxin Less than 1.0 EU per µg of protein as determine by the LAL method.
Reference Data
RefSeq NP_002412
Locus ID 4312
Refseq Size 2081
Cytogenetics 11q22.2
Refseq ORF 1410
Synonyms CLG; CLGN
Summary This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down the interstitial collagens, including types I, II, and III. The gene is part of a cluster of MMP genes on chromosome 11. Mutations in this gene are associated with chronic obstructive pulmonary disease (COPD). Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Protein Families Druggable Genome, Protease, Secreted Protein
Protein Pathways Bladder cancer, Pathways in cancer, PPAR signaling pathway

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Other Versions

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