Fas Ligand (FASLG) (NM_000639) Human Recombinant Protein

CAT#: TP723853

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Purified recombinant protein of Human Fas ligand (TNF superfamily, member 6) (FASLG / TNFSF6)



  View other "FASLG" proteins (3)

USD 255.00


Availability*
5 Days

Size
    • 10 ug


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Specifications

Product Data
Description Purified recombinant protein of Human Fas ligand (TNF superfamily, member 6) (FASLG / TNFSF6)
Species Human
Expression Host CHO
Expression cDNA Clone or AA Sequence Human FASL, the region of N-Met-His8 (Pro134-Leu281), from gene Accession# NM_000639.1
Tag Tag Free
Predicted MW 18 kDa
Concentration Protein formulated and vialed at >50 ug/mL in specified buffer
Purity >90%, as determined by Coomassie stained SDS-PAGE.
Buffer 1 x PBS
Bioactivity The ED50 is 1.5 - 6 ng/ml, corresponding to a specific activity of 1.6 - 6.6 x 10^5 units/mg, determined by the dose dependent stimulation of Jurkat death cell induced by apoptosis.
Endotoxin Less than 0.01 ng per µg protein as determined by the LAL method
Storage Store at -80°C.
Stability Unopened vial can be stored between 2°C and 8°C for up to 2 weeks, at -20°C for up to 6 months, or at -70°C or below until the expiration date. Aliquots can be stored between 2°C and 8°C for up to one week and stored at -20°C or colder for up to 3 months. Avoid repeated freeze/thaw cycles.
Reference Data
RefSeq NP_000630
Locus ID 356
Refseq Size 1909
Cytogenetics 1q24.3
Refseq ORF 843
Synonyms ALPS1B; APT1LG1; APTL; CD95-L; CD95L; CD178; FASL; TNFSF6; TNLG1A
Summary This gene is a member of the tumor necrosis factor superfamily. The primary function of the encoded transmembrane protein is the induction of apoptosis triggered by binding to FAS. The FAS/FASLG signaling pathway is essential for immune system regulation, including activation-induced cell death (AICD) of T cells and cytotoxic T lymphocyte induced cell death. It has also been implicated in the progression of several cancers. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE). Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2014]
Protein Families Druggable Genome, Secreted Protein, Transmembrane
Protein Pathways Allograft rejection, Apoptosis, Autoimmune thyroid disease, Cytokine-cytokine receptor interaction, Graft-versus-host disease, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, Neurotrophin signaling pathway, Pathways in cancer, Type I diabetes mellitus

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