SDF1 (CXCL12) (NM_000609) Human Recombinant Protein

CAT#: TP723843

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Purified recombinant protein of Human chemokine (C-X-C motif) ligand 12 (CXCL12 / SDF-1beta), transcript variant 2


Product Datasheet for 'TP723843'


  View other "CXCL12" proteins (10)

USD 255.00


Availability*
5 Days

Size
    • 10 ug


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Specifications

Product Data
Description Purified recombinant protein of Human chemokine (C-X-C motif) ligand 12 (CXCL12 / SDF-1beta), transcript variant 2
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence Human CXCL12, the region of Ser19-Met93, from gene Accession# NM_000609
Tag Tag Free
Predicted MW 8.8 kDa
Concentration Protein formulated and vialed at >50 ug/mL in specified buffer
Purity >95%, as determined by Coomassie stained SDS-PAGE.
Buffer 1 x PBS
Bioactivity Bioactivity was measured by its property to chemoattract human T cells in a dose dependent manner.
Endotoxin Less than 0.01 ng per µg protein as determined by the LAL method
Reference Data
RefSeq NP_000600
Locus ID 6387
Refseq Size 3560
Cytogenetics 10q11.21
Refseq ORF 279
Synonyms IRH; PBSF; SCYB12; SDF1; TLSF; TPAR1
Summary This antimicrobial gene encodes a stromal cell-derived alpha chemokine member of the intercrine family. The encoded protein functions as the ligand for the G-protein coupled receptor, chemokine (C-X-C motif) receptor 4, and plays a role in many diverse cellular functions, including embryogenesis, immune surveillance, inflammation response, tissue homeostasis, and tumor growth and metastasis. Mutations in this gene are associated with resistance to human immunodeficiency virus type 1 infections. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein
Protein Pathways Axon guidance, Chemokine signaling pathway, Cytokine-cytokine receptor interaction, Leukocyte transendothelial migration

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