TGF beta 3 (TGFB3) (NM_003239) Human Recombinant Protein

CAT#: TP723824

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Purified recombinant protein of Human transforming growth factor, beta 3 (TGFB3)



  View other "TGFB3" proteins (5)

USD 270.00


Availability*
5 Days

Size
    • 5 ug


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Specifications

Product Data
Description Purified recombinant protein of Human transforming growth factor, beta 3 (TGFB3)
Species Human
Expression Host CHO
Expression cDNA Clone or AA Sequence Human TGF-beta;3, the region of Ala301-Ser412, from gene Accession# NM_003239.2
Tag Tag Free
Predicted MW 12.7 kDa
Concentration lot specific
Purity >98%, as determined by Coomassie stained SDS-PAGE.
Buffer 25% Acetonitrile, 0.1% TFA (trifluoroacetic acid)
Bioactivity The ED50 is from 0.10 to 0.4 ng/ml, corresponding to a specific activity of 2.5-10 x 10^6 units/mg.
Endotoxin Less than 0.01 ng per µg protein as determined by the LAL method
Storage Store at -80°C.
Stability Unopened vial can be stored between 2°C and 8°C for up to 2 weeks, at -20°C for up to 6 months, or at -70°C or below until the expiration date. Aliquots can be stored between 2°C and 8°C for up to one week and stored at -20°C or colder for up to 3 months. Avoid repeated freeze/thaw cycles.
Reference Data
RefSeq NP_003230
Locus ID 7043
UniProt ID P10600, A5YM40, B3KVH9
Cytogenetics 14q24.3
Refseq Size 2574
Refseq ORF 1236
Synonyms ARVD; ARVD1; LDS5; RNHF; TGF-beta3
Summary This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. This protein is involved in embryogenesis and cell differentiation, and may play a role in wound healing. Mutations in this gene are a cause of aortic aneurysms and dissections, as well as familial arrhythmogenic right ventricular dysplasia 1. [provided by RefSeq, Aug 2016]
Protein Families Druggable Genome, Secreted Protein, Transmembrane
Protein Pathways Cell cycle, Chronic myeloid leukemia, Colorectal cancer, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM), MAPK signaling pathway, Pancreatic cancer, Pathways in cancer, Renal cell carcinoma, TGF-beta signaling pathway

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