IL17(IL17A) (NM_002190) Human Recombinant Protein

CAT#: TP723780

Purified recombinant protein of Human interleukin 17A and 17F (IL17A / IL-17F) heterodimer


 Product Datasheet for 'TP723780'

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USD 355.00


Availability*
5 Days

Size
    • 10 ug


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Specifications

Product Data
Description Purified recombinant protein of Human interleukin 17A and 17F (IL17A / IL-17F) heterodimer
Species Human
Expression Host E.Coli
Expression cDNA Clone or AA Sequence Human IL-17A, the region of Ile20-Ala155, from gene Accession# NM_002190 and human IL-17F, the region of Arg31-Gln163, from gene Accession# AF384857
Tag Tag Free
Predicted MW 30.6 kDa
Concentration Protein formulated and vialed at >50 ug/mL in specified buffer
Purity >98%, as determined by Coomassie stained SDS-PAGE.
Buffer 10 mM NaH2PO4, 300 mM NaCl, pH7.2
Bioactivity The ED50 is 15-25 ng/ml, corresponding to a specific activity of 6.6 - 4 x 10^4 units/mg. Under this assay the activity was comparable to other vendor's cytokine.
Endotoxin Less than 0.1 EU/µg (<0.01 ng/µg) protein as determined by the LAL method.
Reference Data
RefSeq NP_002181
Locus ID 3605
Refseq Size 1859
Cytogenetics 6p12.2
Refseq ORF 465
Synonyms CTLA8; IL-17; IL-17A; IL17; CTLA-8
Summary The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008]
Protein Families Secreted Protein, Druggable Genome
Protein Pathways Cytokine-cytokine receptor interaction

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