PDGF Receptor beta (PDGFRB) (NM_002609) Human Recombinant Protein

CAT#: TP723757

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Purified recombinant protein of Human platelet-derived growth factor receptor, beta polypeptide (PDGFRB / PDGF-BB)



  View other "PDGFRB" proteins (7)

USD 205.00


Availability*
5 Days

Size
    • 10 ug


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Specifications

Product Data
Description Purified recombinant protein of Human platelet-derived growth factor receptor, beta polypeptide (PDGFRB / PDGF-BB)
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence Human PDGF-BB, the region of Ser82-Thr190, from gene Accession# NM_033016
Tag Tag Free
Predicted MW 12.3 kDa
Concentration Protein formulated and vialed at >50 ug/mL in specified buffer
Purity >98%, as determined by Coomassie stained SDS-PAGE.
Buffer 29% acetonitrile, 0.1% TFA (trifluoroacetic acid)
Bioactivity The ED50 is 10-20 ng/ml, corresponding to a specific activity of 1-0.5 x 10^5 units/mg, determined by the dose dependent stimulation of 3T3 cell proliferation. The bioactivity is equivalent to competitor reported values.
Endotoxin Less than 0.01 ng per µg protein as determined by the LAL method
Storage Store at -80°C.
Stability Unopened vial can be stored between 2°C and 8°C for up to 2 weeks, at -20°C for up to 6 months, or at -70°C or below until the expiration date. Aliquots can be stored between 2°C and 8°C for up to one week and stored at -20°C or colder for up to 3 months. Avoid repeated freeze/thaw cycles.
Reference Data
RefSeq NP_002600
Locus ID 5159
Refseq Size 5718
Cytogenetics 5q32
Refseq ORF 3318
Synonyms CD140B; IBGC4; IMF1; JTK12; KOGS; PDGFR; PDGFR-1; PDGFR1; PENTT
Summary The protein encoded by this gene is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer (PDGFB or PDGFD) or a heterodimer (PDGFA and PDGFB). This gene is essential for normal development of the cardiovascular system and aids in rearrangement of the actin cytoskeleton. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the ETV6 gene, results in chronic myeloproliferative disorder with eosinophilia. [provided by RefSeq, Aug 2017]
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase, Transmembrane
Protein Pathways Calcium signaling pathway, Colorectal cancer, Cytokine-cytokine receptor interaction, Focal adhesion, Gap junction, Glioma, MAPK signaling pathway, Melanoma, Pathways in cancer, Prostate cancer, Regulation of actin cytoskeleton

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