IL17(IL17A) (NM_002190) Human Recombinant Protein

CAT#: TP723711

Purified recombinant protein of Human interleukin 17A (IL17A)

Product images

Specifications

Product Data

• Description: Purified recombinant protein of Human interleukin 17A (IL17A)
• Species: Human
• Expression Host: E.Coli
• Expression cDNA Clone or AA Sequence: Human IL-17A, the region of Ile20-Ala155, from gene Accession# NM_002190
• Tag: Tag Free
• Predicted MW: 15.7 kDa
• Concentration: Protein formulated and vialed at >50 ug/mL in specified buffer
• Purity: Purity is >98%, as determined by Coomassie stained SDS-PAGE.
• Buffer: 10mM NaH2PO4, 300mM NaCl, pH7.2
• Bioactivity: The ED50 is 2 - 4 ng/ml, corresponding to a specific activity 5 - 2.5 x 10^5 units/mg, determined by a dose dependent stimulation of normal human dermal fibroblasts production of IL-6.
• Endotoxin: Less than 0.01 ng per ug protein as determined by the LAL method.

Reference Data

• RefSeq: NP_002181
• Locus ID: 3605
• Refseq Size: 1859
• Cytogenetics: 6p12.2
• Refseq ORF: 465
• Synonyms: CTLA8; IL-17; IL-17A; IL17; CTLA-8
• Summary: The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008]
• Protein Families: Secreted Protein, Druggable Genome
• Protein Pathways: Cytokine-cytokine receptor interaction