IL17 (IL17A) (NM_002190) Human Recombinant Protein
Specifications
Product Data | |
Description | Purified recombinant protein of Human interleukin 17A (IL17A) |
Species | Human |
Expression Host | E. coli |
Tag | Tag Free |
Predicted MW | 15.7 kDa |
Concentration | Protein formulated and vialed at >50 ug/mL in specified buffer |
Purity | Purity is >98%, as determined by Coomassie stained SDS-PAGE. |
Buffer | 10mM NaH2PO4, 300mM NaCl, pH7.2 |
Bioactivity | The ED50 is 2 - 4 ng/ml, corresponding to a specific activity 5 - 2.5 x 10^5 units/mg, determined by a dose dependent stimulation of normal human dermal fibroblasts production of IL-6. |
Endotoxin | Less than 0.01 ng per ug protein as determined by the LAL method |
Reference Data | |
RefSeq | NP_002181 |
Locus ID | 3605 |
Refseq Size | 1859 |
Cytogenetics | 6p12.2 |
Refseq ORF | 465 |
Synonyms | CTLA-8; CTLA8; IL-17; IL-17A; IL17 |
Summary | The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008] |
Protein Families | Druggable Genome, Secreted Protein |
Protein Pathways | Cytokine-cytokine receptor interaction |
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Resources
Protein Resources |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
TP318057 | Recombinant protein of human interleukin 17A (IL17A) |
USD 748.00 |
|
PH318057 | IL17A MS Standard C13 and N15-labeled recombinant protein (NP_002181) |
USD 1,995.00 |
|
TP723199 | Purified recombinant protein of Human interleukin 17A (IL17A). |
USD 230.00 |
|
LC400795 | IL17A HEK293T cell transient overexpression lysate (as WB positive control) |
USD 95.00 |
|
TP720016 | Recombinant protein of human interleukin 17A (IL17A) |
USD 299.00 |
|
AR51903PU-N | Recombinant human IL17A, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
USD 1,070.00 |
|
TP723780 | Purified recombinant protein of Human interleukin 17A and 17F (IL17A / IL-17F) heterodimer |
USD 355.00 |
|
LY400795 | Transient overexpression lysate of interleukin 17A (IL17A) |
USD 315.00 |
|
AR51903PU-S | Recombinant human IL17A, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques. |
USD 320.00 |
USD 360.00