IL17 (IL17A) (NM_002190) Human Recombinant Protein

CAT#: TP723711

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Purified recombinant protein of Human interleukin 17A (IL17A)


 Product Datasheet for 'TP723711'

  View other "IL17A" proteins (9)

USD 195.00


Availability*
5 Days

Size
    • 10 ug


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Specifications

Product Data
Description Purified recombinant protein of Human interleukin 17A (IL17A)
Species Human
Expression Host E. coli
Tag Tag Free
Predicted MW 15.7 kDa
Concentration Protein formulated and vialed at >50 ug/mL in specified buffer
Purity Purity is >98%, as determined by Coomassie stained SDS-PAGE.
Buffer 10mM NaH2PO4, 300mM NaCl, pH7.2
Bioactivity The ED50 is 2 - 4 ng/ml, corresponding to a specific activity 5 - 2.5 x 10^5 units/mg, determined by a dose dependent stimulation of normal human dermal fibroblasts production of IL-6.
Endotoxin Less than 0.01 ng per ug protein as determined by the LAL method
Reference Data
RefSeq NP_002181
Locus ID 3605
Refseq Size 1859
Cytogenetics 6p12.2
Refseq ORF 465
Synonyms CTLA-8; CTLA8; IL-17; IL-17A; IL17
Summary The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008]
Protein Families Druggable Genome, Secreted Protein
Protein Pathways Cytokine-cytokine receptor interaction

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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