TGF beta 3 (TGFB3) (NM_003239) Human Recombinant Protein

CAT#: TP723442

Purified recombinant protein of Human transforming growth factor, beta 3 (TGFB3).


 Product Datasheet for 'TP723442'

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USD 230.00


Availability*
5 Days

Size
    • 10 ug


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Specifications

Product Data
Description Purified recombinant protein of Human transforming growth factor, beta 3 (TGFB3).
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence ALDTNYCFRNLEENCCVRPLYIDFRQDLGWKWVHEPKGYYANFCSGPCPYLRSADTTHSTVLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVEQLSNMVVKSCKCS
Tag Tag Free
Predicted MW 25 kDa
Concentration Resuspend the protein in the desired concentration in proper buffer
Purity >95% as determined by SDS-PAGE and Coomassie blue staining
Buffer Lyophilized from a 0.2 µM filtered solution of 20mM phosphate buffer,100mM NaCl, pH 7.2
Bioactivity ED50 was determined by TGF-beta3's ability to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells is less than or equal to 0.05 ng/ml, corresponding to a specific activity of >2 x 10^7 units/mg.
Endotoxin Endotoxin level is <0.1 ng/µg of protein (<1EU/µg).
Reference Data
RefSeq NP_003230
Locus ID 7043
Refseq Size 2574
Cytogenetics 14q24.3
Refseq ORF 1236
Synonyms ARVD; ARVD1; LDS5; RNHF; TGF-beta3
Summary This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. This protein is involved in embryogenesis and cell differentiation, and may play a role in wound healing. Mutations in this gene are a cause of aortic aneurysms and dissections, as well as familial arrhythmogenic right ventricular dysplasia 1. [provided by RefSeq, Aug 2016]
Protein Families Druggable Genome, Secreted Protein, Transmembrane
Protein Pathways Cell cycle, Chronic myeloid leukemia, Colorectal cancer, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM), MAPK signaling pathway, Pancreatic cancer, Pathways in cancer, Renal cell carcinoma, TGF-beta signaling pathway

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