IL17 (IL17A) (NM_002190) Human Recombinant Protein

CAT#: TP723199

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Purified recombinant protein of Human interleukin 17A (IL17A).


 Product Datasheet for 'TP723199'

  View other "IL17A" proteins (9)

USD 240.00


Availability*
5 Days

Size
    • 25 ug


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Specifications

Product Data
Description Purified recombinant protein of Human interleukin 17A (IL17A).
Species Human
Expression Host E. coli
Tag Tag Free
Predicted MW 31.3 kDa
Concentration Resuspend the protein in the desired concentration in proper buffer
Purity >95% as determined by SDS-PAGE and Coomassie blue staining
Buffer Lyophilized from a 0.2 µM filtered solution of 20mM phosphate buffer,100mM NaCl, pH 7.2
Bioactivity Assay #1: ED50 as determined by the dose-dependent induction of IL-6 in primary human foreskin fibroblasts was found to be approximately 2 ng/ml. Assay #2: Measured by its ability to induce IL-6 production by NHDF cells.
Endotoxin Endotoxin level is < 0.1 ng/µg of protein (< 1 EU/µg)
Reference Data
RefSeq NP_002181
Locus ID 3605
Refseq Size 1859
Cytogenetics 6p12.2
Refseq ORF 465
Synonyms CTLA-8; CTLA8; IL-17; IL-17A; IL17
Summary The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008]
Protein Families Druggable Genome, Secreted Protein
Protein Pathways Cytokine-cytokine receptor interaction

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