GDF7 (NM_182828) Human Recombinant Protein
Purified recombinant protein of Human growth differentiation factor 7 (GDF7).
Product Datasheet for 'TP723136'
|Description||Purified recombinant protein of Human growth differentiation factor 7 (GDF7).|
|Expression Host||E. coli|
|Expression cDNA Clone or AA Sequence||TALAGTRTAQGSGGGAGRGHGRRGRSRCSRKPLHVDFKELGWDDWIIAPLDYEAYHCEGLCDFPLRSHLEPTNHAIIQTLLNSMAPDAAPASCCVPARLSPISILYIDAANNVVYKQYEDMVVEACGCR|
|Predicted MW||28 kDa|
|Concentration||Resuspend the protein in the desired concentration in proper buffer|
|Purity||>95% as determined by SDS-PAGE and Coomassie blue staining|
|Buffer||Lyophilized from a 0.2 µM filtered solution of 20mM phosphate buffer,100mM NaCl, pH 7.2|
|Bioactivity||Determined by its ability to inhibit induced alkaline phosphatase production by ATDC-5 chondrogenic cells.|
|Endotoxin||Endotoxin level is <0.1 ng/µg of protein (<1EU/µg).|
|Summary||This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein may play a role in the differentiation of tendon cells and spinal cord interneurons. A mutation in this gene may be associated with increased risk for Barrett's esophagus and esophageal adenocarcinoma. [provided by RefSeq, Sep 2016]|
|Protein Families||Adult stem cells, Cancer stem cells, Druggable Genome, Embryonic stem cells, ES Cell Differentiation/IPS, Secreted Protein, Stem cell relevant signaling - TGFb/BMP signaling pathway|
|Protein Pathways||TGF-beta signaling pathway|
|LC405371||Transient overexpression lysate of growth differentiation factor 7 (GDF7)||