SFRP1 (NM_003012) Human Recombinant Protein
Purified recombinant protein of Human secreted frizzled-related protein 1 (SFRP1).
Product Datasheet for 'TP723118'
|Description||Purified recombinant protein of Human secreted frizzled-related protein 1 (SFRP1).|
|Expression cDNA Clone or AA Sequence||SEYDYVSFQSDIGPYQSGRFYTKPPQCVDIPADLRLCHNVGYKKMVLPNLLEHETMAEVKQQASSWVPLLNKNCHAGTQVFLCSLFAPVCLDRPIYPCRWLCEAVRDSCEPVMQFFGFYWPEMLKCDKFPEGDVCIAMTPPNATEASKPQGTTVCPPCDNELKSEAIIEHLCASEFALRMKIKEVKKENGDKKIVPKKKKPLKLGPIKKKDLKKLVLYLKNGADCPCHQLDNLSHHFLIMGRKVKSQYLLTAIHKWDKKNKEFKNFMKKMKNHECPTFQSVFK|
|Predicted MW||31.1 kDa|
|Concentration||Resuspend the protein in the desired concentration in proper buffer|
|Purity||>95% as determined by SDS-PAGE and Coomassie blue staining|
|Buffer||Lyophilized from a 0.2 µM filtered solution of 20mM phosphate buffer,100mM NaCl, pH 7.2|
|Bioactivity||Determined by its ability to inhibit BMP-2 proliferation effect of ATDC-5 cells. The expected ED50 is 0.3-0.5ug/mL.|
|Endotoxin||Endotoxin level is <0.1 ng/µg of protein (<1EU/µg).|
|Synonyms||FRP; FRP-1; FRP1; FrzA; SARP2|
|Summary||This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina. [provided by RefSeq, Sep 2009]|
|Protein Families||Adult stem cells, Cancer stem cells, Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein, Stem cell relevant signaling - Wnt Signaling pathway, Transmembrane|
|Protein Pathways||Wnt signaling pathway|